Correct direction
Most domestic machines are designed for the top of the handwheel to turn toward you. Reversing it can introduce slack or disturb the hook path.
When manual control helps
Use it to raise the take-up lever, place the needle at a corner, check a wide stitch, or ease through one difficult penetration.
When it will not turn
Do not force it. Trapped thread, a displaced bobbin case, a bent needle, or bobbin-winder engagement may be blocking the mechanism.